PAION was formed in 2000 in Aachen. Since its inception, the founders, Mariola Söhngen, MD and Wolfgang Söhngen, MD focused on the clinical development of CNS compounds.
PAION took over the development of Remimazolam as a pre-IND candidate in 2008 and has successfully developed it to a Phase III compound. Following successful funding activities (EUR 61 million) in 2014, a Phase III program has been initiated in 2015 EU and US global registration. In 2017 the remimazolam Phase III development program in the U.S. in procedural sedation has been completed. First market approval followed in 2020 first in Japan, followed by the U.S. and China. At the beginning of 2021, the two products angiotensin II and eravacycline were then added to the portfolio through a licensing agreement with La Jolla for Europe.
Until 2008, PAION's focus was on stroke with Desmoteplase for which all remaining rights were sold to Lundbeck in 2012 in order to accelerate the development of Remimazolam.
Distribution partnership with Viatris in Europe
Partnership with Cristalia in Latin America
Sale of patent rights in China to Humanwell
Marketing authorization for remimazolam in South Korea
Licensing agreement with La Jolla for GIAPREZA™ and XERAVA™ in Europe
Marketing authorization for remimazolam in the EU/EEA
First marketing authorization in Japan in general anesthesia
First marketing authorization in the U.S. in procedural sedation
Marketing authorization in China in general anesthesia
First own filing in procedural sedation in the EU
Submission of new drug application for remimazolam by Cosmo Pharmaceuticals in the U.S.
1st filing in general anesthesia in Japan by Mundipharma
1st filing in procedural sedation in China by Yichang Humanwell
Start of Phase III trial in general anesthesia in the EU
Completion of the remimazolam Phase III development program in the U.S. in procedural sedation
Cosmo becomes partner for Remimazolam in the U.S.
Completion of U.S. Phase III colonoscopy trial
Start of the Remimazolam Phase III programms in procedural sedation in the U.S. and general anesthesia in the EU
Capital measures of EUR 61 million secured for Remimazolam Phase III programs
PAION, Inc. founded in the U.S.
Japanese Phase III program with Remimazolam successfully completed
Several license agreements with national champions in the anesthesia space (“String of pearls" strategy)
The sale of all Desmoteplase rights to Lundbeck (EUR 20 million) allows PAION to accelerate the development of Remimazolam
PAION completes Phase II program in procedural sedation in the U.S.
PAION acquires CeNeS Pharmaceuticals plc with the candidate compounds Remimazolam, M6G, GGF2
First Desmoteplase Phase III trial (DIAS 2) fails to meet primary endpoint, PAION identifies suitable patient population and successfully expands partnership with Lundbeck
PAION AG initial public offering and license agreement for Desmoteplase with Lundbeck
PAION closes agreement with Forest Inc. for Desmoteplase in the North American markets
PAION closes third funding round of EUR 8.4 million upon successful completion of Desmoteplase Phase II trial (DIAS 2)
Start of Desmoteplase Phase II trial in ischemic stroke (DIAS)
PAION is founded (Founders: Dr. W. Söhngen, Dr. M. Söhngen)